HH1 — Verticillium dahliae

Summary

VDAG_06636, designated VdHH1 (also known as VdNPKA, VdPKAC2, and STK-13) in Verticillium dahliae on chromosome DS572708, encodes a cyclin-dependent kinase (CDK) with RNA polymerase II C-terminal domain S2 kinase activity, protein serine/threonine kinase activity, and cyclin binding. The gene is associated with ethylene anabolism, positive regulation of glycogenolysis and triglyceride catabolism, activation of mycose catabolism, regulation of mitotic cell cycle and spindle assembly, and protein localization to the nuclear periphery and chromatin. Its product localizes to the nuclear cyclin-dependent protein kinase holoenzyme complex, P-TEFb complex, and Ctk complex. Studies of related genes in other species link the family to pathogenicity and growth regulation, though this has not been established for VdHH1 itself.