LAC1 — Verticillium dahliae

Summary

VDAG_06672 (LAC1, VdLAC1) in Verticillium dahliae encodes a sphingosine N-acyltransferase (Lac1/Lag1-like family) with ceramide synthase activity, localised to the endoplasmic reticulum. The gene is associated with ceramide and melanin biosynthesis, as well as the meiotic cell cycle. It has been linked to numerous phenotypes including altered endocytosis, cell cycle progression, budding, mating response, apoptosis, autophagy, and resistance to osmotic, alkaline, and acidic stress. Associations also include changes in chitin deposition, protein secretion, respiratory metabolism, starvation survival, and mutation frequency.