DRS2 — Verticillium dahliae

Summary

VDAG_06574 (DRS2, VdDRS2) in Verticillium dahliae encodes a P-type ATPase family member with lysophosphatidylserine, glycoceramide, phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine flippase activity, as well as potassium:proton transporter activity. The gene is associated with phospholipid and ceramide translocation, potassium ion export, endocytic recycling, post-Golgi transport, sporulation, secretion, endocytosis, and establishment of cell polarity. It localizes to the trans-Golgi network membrane, endosome membrane, division septum, and the Cdc50p-Drs2p complex. Phenotypic associations include increased virulence, abnormal filamentous and pseudohyphal growth, decreased axial and bipolar budding, abnormal Golgi morphology, increased alkaline pH resistance, and altered respiratory metabolism. The gene is linked to vascular wilt disease in cotton and Arabidopsis.