HH1 — Verticillium dahliae

Summary

VDAG_06489, designated VdHH1 (also known as VdNPKA, VdPKAC2, and STK-13) in Verticillium dahliae on chromosome DS572706, encodes an Aurora kinase with protein serine/threonine kinase activity, including cAMP-dependent protein kinase A and histone H3S10 kinase activities. This gene is associated with ethylene anabolism, mitotic spindle assembly checkpoint regulation, sister chromatid segregation, and meiotic chromosome segregation. The encoded protein localizes to the kinetochore microtubule, spindle midzone, and the CPC complex. VdHH1 is associated with the regulation of organelle assembly and the positive regulation of the mitotic cell cycle spindle assembly checkpoint. Studies of related genes in other species connect the family to lethal phenotypes and fusarium ear blight, though these associations are not yet established in V. dahliae.