PKAA — Verticillium dahliae

Summary

VDAG_06474, designated VdPKAA (also known as PKAC or PKAA) in Verticillium dahliae on chromosome DS572706, encodes a protein with cAMP-dependent protein kinase activity, serine/threonine kinase activity, ribosomal protein S6 kinase activity, and signaling adaptor activity. The gene is associated with the glucose-sensing PKA pathway, positive regulation of cytoplasmic translation and ribosomal protein gene transcription, regulation of response to osmotic stress, and downregulation of filamentous growth. It is linked to host gene-for-gene resistance suppression, microtubule destabilization, and regulation of sphingolipid biosynthesis. The product localizes to the cAMP-dependent protein kinase complex, division septum, nucleoplasm, nuclear envelope, fungal-type vacuole, cell tip, and chromatin. Studies of related genes in other species link the family to loss of pathogenicity and reduced virulence, as well as associations with fusarium head blight and aspergillosis.