PDA1 — Verticillium dahliae

Summary

VdPDA1 (VDAG_06356) on chromosome DS572706 of Verticillium dahliae encodes the E1 alpha subunit of the pyruvate dehydrogenase complex, with pyruvate dehydrogenase (lipoamide) activity (EC 1.2.4.1) and metal binding. The gene is associated with the pyruvate dehydrogenase pathway, pseudohyphal growth, and localizes to mitochondria, the mitochondrial lumen, mitochondrial nucleoid, and the pyruvate dehydrogenase complex. It is linked to numerous phenotypes including abnormal carbon source utilization, altered cell cycle progression through G1/S and G2/M phases, delayed fermentative and decreased respiratory metabolism, absent nuclear export and protein secretion, increased X-ray resistance, and abnormal autophagy, mitophagy, pexophagy, and micronucleophagy. Related genes in other species are linked to oxidative stress response and decreased pseudohyphal growth.