HH1 — Verticillium dahliae

Summary

VDAG_06262, designated VdHH1 (also known as VdNPKA, VdPKAC2, and STK-13) in Verticillium dahliae on chromosome DS572707, encodes an epsin-3 protein containing an ENTH/VHS domain. The gene product is annotated for phosphatidylinositol 4,5-bisphosphate binding, membrane bending activity, clathrin binding, and phospholipid binding. VdHH1 is associated with ethylene anabolism, endocytosis, TGN-to-endosome transport, retrograde transport from endosome to Golgi, actin filament and cytoskeleton organization, and spore germination. The protein localizes to clathrin vesicle coats, the trans-Golgi network, actin patches, endosomes, the Golgi complex, the plasma membrane, and the cytosol. Studies of related genes in other species link the family to additional regulatory and vesicle-trafficking domains.