CP1 — Verticillium dahliae

Summary

VdCP1 (VDAG_05758) in Verticillium dahliae encodes a serine carboxypeptidase (EC 3.4.16.5) with a peptidase S10 domain and an AB hydrolase fold, classified as Carboxypeptidase Y homolog A. The gene is associated with proteolysis, secretion, and methylation, and its product localizes to the fungal-type vacuole lumen. VdCP1 is associated with numerous cellular processes including autophagy, mitophagy, pexophagy, ribophagy, endocytosis, cytokinesis, nuclear fusion during mating, prion inheritance, and cell death regulation. It is also linked to acquired thermotolerance, replicative lifespan, Golgi morphology, and protein/peptide accumulation. Sequence similarity suggests the family may function as an apoplastic effector in related fungi.