SKP1 — Verticillium dahliae

Summary

VDAG_05788, designated VdSKP1 (synonyms SCON-3, VdSCON-3, SKP1) in Verticillium dahliae, encodes a protein containing SKP1-like and BTB/POZ domains that binds cullin family proteins and exhibits kinase activity. The gene is associated with protein ubiquitination and ubiquitin-dependent proteolysis, as well as defense and immune responses, cell death, signal transduction, secretion, mitotic cell cycle regulation, and resolution of meiotic recombination intermediates. VdSKP1 has been linked to numerous cell cycle phenotypes including premature anaphase progression, altered G1/S and G2/M transitions, decreased M phase progression, and increased rate of passage through START. It is also associated with decreased flocculation and adhesion, abnormal bipolar budding and pseudohyphal growth, delayed sporulation and carbon source utilization, decreased redox state, and increased mating efficiency. The protein localizes to the cytoplasm, nucleus, and ssDNA-dependent DNA helicase and RAVE complexes.