BIP1 — Verticillium dahliae

Summary

VDAG_05516, designated VdBIP1 (also known as VdKAR2, VdGRP78, BIP1, BIPA, GRP78) in Verticillium dahliae on chromosome DS572704, encodes an Hsp70 family chaperone with ATP hydrolase activity and protein translocase activity, localizing to the endoplasmic reticulum lumen and ER chaperone complex. The gene is associated with the IRE1 branch of the unfolded protein response, ERAD pathway, protein refolding, secretion, and fungal-type cell wall beta-glucan biosynthesis. VdBIP1 has been linked to traits including hydrogen peroxide content, increased adhesion, abnormal colony color, increased polyploidy and aneuploidy, delayed cell cycle progression, decreased cell fusion, and altered necrotic cell death. Related genes in other species are associated with nuclear fusion during mating, recovery from pheromone-induced cell cycle arrest, and pexophagy.