ABCA — Verticillium dahliae

Summary

VDAG_05293, designated VdABCA (also known as VdPDR5, PDR18, VdSNQ2, and other synonyms), encodes an ABC transporter of the pleiotropic drug resistance (PDR/CDR) subfamily on Verticillium dahliae chromosome DS572704. The protein contains ABC transporter and AAA+ ATPase domains and exhibits ATP hydrolase and ATP binding activities. VdABCA is associated with xenobiotic detoxification via transmembrane export across the plasma membrane, response to toxic substances, virus-induced PTGS, and zearalenone biosynthetic process. It localizes to the vacuolar membrane and plasmalemma. The gene has been connected to plant height, leaf number, root length, and drought tolerance, as well as altered small molecule transport, increased sporulation rate, decreased cell death, and abnormal vacuolar distribution, cell cycle progression, and replicative lifespan. Studies of related genes in other species link the family to virulence and pathogenicity.