MCM7 — Verticillium dahliae

Summary

VDAG_04238, designated VdMCM7 (also known as VdCDC47), encodes an MCM family protein with 3'-5' DNA helicase activity, ATP hydrolase activity, and DNA replication origin binding. In Verticillium dahliae, VdMCM7 is associated with the MCM complex and CMG complex, and localizes to chromatin, heterochromatin, telomeric regions, and the nuclear replication fork. The gene is associated with mitotic and premeiotic DNA replication, DNA replication initiation and elongation, double-strand break repair via break-induced replication, and DNA replication-dependent chromatin assembly. Phenotypic associations include cell cycle progression through G1/S and G2/M phase transitions, S phase progression, sporulation, mating response, meiosis, chromosome segregation, silencing, and chronological lifespan. VdMCM7 is also associated with telomeric silencing and heterochromatin maintenance. Studies of related genes in other species link the family to replication licensing and cell cycle control.