ABCA — Verticillium dahliae

Summary

VDAG_04004 (VdABCA) encodes a multidrug resistance protein CDR2 belonging to the ABCG/PDR family, with ATP hydrolase activity and floppase activity for phosphatidylethanolamine, phosphatidylcholine, and phosphatidylserine, as well as ABC-type xenobiotic transporter activity. The gene is associated with response to xenobiotic stimulus, xenobiotic detoxification by transmembrane export across the plasma membrane, cellular monoatomic cation homeostasis, and virus-induced PTGS. It localizes to the plasma membrane, membrane, and extracellular vesicles. VdABCA is associated with traits including leaf number, plant height, root length, and drought tolerance, and with phenotypes such as altered sporulation, cell death, cell cycle progression, vacuolar distribution and transport, endocytosis, mitophagy, pseudohyphal growth, and nutrient uptake. Studies of related genes in other species link the family to oxidative stress response, protein content, and phosphate content.