scd1 — Verticillium dahliae

Summary

VDAG_03774 (scd1) in Verticillium dahliae encodes a protein containing a guanine nucleotide exchange factor (GEF) domain for CDC42, along with DH, PH, and PB1 domains, and is annotated with guanyl-nucleotide exchange factor (GDS) activity and lipid binding. The gene is associated with the regulation of mitotic spindle organization, septin ring organization, division septum assembly, endocytosis, bipolar cell polarity, and intracellular signal transduction. It is also linked to conidia formation, melanin anabolism, and cell polarization. The encoded protein localizes to the cleavage furrow, division septum, cell tip, mating projection tip, and mitotic spindle. Related genes in other species are linked to the Cdc42 GTPase complex.