TRX — Verticillium dahliae

Summary

VdTRX (VDAG_03464) encodes a thioredoxin, a small redox protein with protein-disulfide reductase and antioxidant activity. In Verticillium dahliae, this gene is associated with defense response, cellular detoxification of hydrogen peroxide, cell redox homeostasis, and host invasion. It is associated with toxic metabolite repair, virus-induced post-transcriptional gene silencing, and negative regulation of transcription by RNA polymerase II. The protein localises to the cytoplasm, nucleus, mitochondria, vacuole, and nuclear periphery. Phenotypic associations include abnormal colony shape, decreased cell death, increased starvation resistance, altered autophagy, and defects in cytokinesis, septum formation, protein secretion, and respiratory metabolism. Related genes in other species link the family to oxidative stress response.