ABCA — Verticillium dahliae

Summary

VDAG_03604, symbol ABCA and also known as VdABCA, encodes an ABCG-type pleiotropic drug resistance (PDR) transporter with ATP-coupled transmembrane transporter activity, ATP hydrolase activity and ATP binding, localised to the plasma membrane. In Verticillium dahliae, the gene is associated with response to antibiotic, xenobiotic detoxification by transmembrane export across the plasma membrane, and virus-induced post-transcriptional gene silencing. Associations with plant traits include leaf number, plant height, root length and drought tolerance. Phenotypic connections encompass abnormal small molecule transport, increased sporulation rate, decreased cell death rate, altered vacuolar distribution and transport, delayed mitophagy, abnormal chronological and replicative lifespan, and altered nutrient uptake, cell cycle progression, pseudohyphal growth and shmoo formation. Studies of related genes in other species link the family to oxidative stress response, protein content and phosphate content.