HOC1 — Verticillium dahliae

Summary

VdHOC1 (VDAG_02820) on chromosome DS572698 of Verticillium dahliae encodes a glycolipid 6-alpha-mannosyltransferase (EC 2.4.1.232) belonging to the Och1-like family, with 1,6-alpha-mannosyltransferase activity. The gene is associated with N-glycan processing, glycoprotein and cell wall mannoprotein anabolism, and protein N-linked glycosylation. It localises to the Golgi complex, ER membrane, and mannan polymerase complexes. VdHOC1 is associated with cellular responses to heat and starvation, and with filamentous growth. The gene is also linked to sunflower yellow wilt disease caused by V. dahliae. Phenotypic associations include abnormal Golgi morphology, septum formation, bipolar budding pattern, and spore wall formation, along with decreased or absent spore germination, budding, shmoo formation, filamentous growth, mating efficiency, and pheromone sensitivity, as well as delayed cell cycle progression and increased polyploidy.