HH1 — Verticillium dahliae

Summary

VdHH1 (VDAG_02641) on chromosome DS572698 of Verticillium dahliae encodes a protein with cAMP-dependent protein kinase activity, serine/threonine kinase activity, ATP binding, lipid binding, and identical protein binding functions. It is associated with ethylene anabolism, regulation of osmotic stress response, hydrogen sulfide anabolism, microtubule destabilization, downregulation of host gene-for-gene resistance, actomyosin organization, TORC2 signaling, sphingolipid biosynthesis, exocytosis, and ribosomal protein gene transcription. The protein localizes to the cAMP-dependent protein kinase complex, growing cell tips, cytoskeleton, bud sites, mating projection tips, bud necks, nucleoplasm, cell cortex, and fungal vacuoles. Studies of related genes in other species link the family to reduced virulence, though this is not established for VdHH1 itself.