ABCA — Verticillium dahliae

Summary

VDAG_02707 (ABCA, VdABCA) in Verticillium dahliae encodes a pleiotropic ABC multiple drug efflux transporter, a member of the PDR/CDR subfamily with ATP-binding and transmembrane domains. The gene is associated with ATP hydrolase activity, ATP binding, and xenobiotic detoxification via transmembrane export across the plasma membrane, as well as response to toxic substances and virus-induced PTGS. It localises to the plasma membrane. Associations with plant traits include leaf number, plant height, root length, and drought tolerance. Phenotypic links encompass abnormal small molecule transport, increased sporulation rate, altered vacuolar distribution and transport, decreased cell death rate, delayed mitophagy, and abnormal replicative and chronological lifespan. Studies of related genes in other species link the family to reduced virulence and unaffected pathogenicity, and to traits such as protein and phosphate content.