FREB — Verticillium dahliae

Summary

VDAG_02360 (FREB) in Verticillium dahliae encodes a ferric-chelate reductase (NADPH) with NADH:Fe3+ oxidoreductase activity, belonging to the ferric/cupric reductase family. The gene is associated with cellular iron ion homeostasis, iron transport, and copper ion import, and its product localises to the plasma membrane. Studies of related genes in other species link the FREB family to reduced virulence and vascular wilt disease, though these associations are not yet established for V. dahliae itself. The gene shares sequence similarity with ferric oxidoreductase domain-containing proteins from related species, and its product contains multiple FAD-binding and NAD-binding domains characteristic of transmembrane reductases involved in metal ion acquisition.