ERG1 — Verticillium dahliae

Summary

VdERG1 (VDAG_01934) on chromosome DS572697 of Verticillium dahliae encodes a squalene epoxidase (EC 1.14.14.17) with squalene monooxygenase activity and FAD/NAD-binding domains. The gene is associated with ergosterol metabolism and anabolism, electron transfer, and cellular responses to starvation, xenobiotic stimulus, and biotic stimulus. It is linked to filamentous growth, cell growth mode switching from budding to filamentous, and localization to the endoplasmic reticulum, vacuolar membrane, plasma membrane, cytoplasm, and adiposomes. Phenotypic associations include decreased invasive growth, abnormal septum formation and cytokinesis, absent anaerobic growth and endocytosis, increased vegetative growth rate, and altered mating response, nutrient uptake, and redox state. Related genes in other species include ERG1, ERG26, ERG11, ERG2, ERG25, BUD27, and RSP5.