ETR1 — Verticillium dahliae

Summary

VDAG_01873 (VdETR1, also known as MRF1) in Verticillium dahliae encodes a protein with NADPH dehydrogenase (quinone) activity, NADH dehydrogenase (quinone) (non-electrogenic) activity, trans-2-enoyl-CoA reductase (NADPH) activity, enoyl-[acyl-carrier-protein] reductase (NADPH) activity, sequence-specific DNA binding, and DNA binding transcription factor activity. The protein contains Mito_Enoyl-ACP_Reductase, ADH-like_N, and GroES-like_sf domains and is localised to the mitochondria, mitochondrial lumen, and cytoplasm. VdETR1 is associated with induced systemic resistance, defense response, fatty acid metabolism, and fatty acid anabolism. The gene is linked to numerous phenotypes including decreased cell cycle progression in M phase, abnormal colony color, decreased radiation resistance, increased cell death, decreased respiratory metabolism, increased desiccation resistance, increased mitophagy, increased viability, decreased biofilm formation, increased filamentous growth, and altered carbon source utilization. Studies of related genes in other species connect the family to chlorophyll content, oxidative stress response, and acid sensitivity.