DBF2 — Verticillium dahliae

Summary

VDAG_01807 (DBF2, VdDBF2) encodes a non-specific serine/threonine protein kinase with protein serine/threonine kinase activity (EC 2.7.11.1), belonging to the AGC kinase family. In Verticillium dahliae, this gene is associated with induced systemic resistance, regulation of protein secretion, filamentous growth, biofilm formation, and cellular salinity response. It is linked to cell cycle progression, particularly mitotic cytokinesis checkpoint control, actomyosin organization, and septum biogenesis. The encoded protein localizes to the hyphal tip, spindle, actomyosin contractile ring, and cross wall. Phenotypic associations include abnormal cell cycle progression, absent septum formation, delayed chromosome segregation, decreased lifespan, and altered budding patterns. Related genes in other species link the family to the Sid2-Mob1 complex.