CPR1 — Verticillium dahliae

Summary

VdCPR1 (VDAG_01004) of Verticillium dahliae encodes a cyclophilin-type peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) with cyclosporin A binding activity, localised to the ER lumen, cytoplasm, nucleus, fungal-type vacuole and spindle pole body. The gene is associated with protein folding, mRNA cis splicing via the spliceosome, and secondary metabolism. Phenotypic associations include increased RNA accumulation and sporulation rate, altered colony size, abnormal cytokinesis and spore wall formation, increased osmotic stress resistance, decreased nutrient uptake and vacuolar transport, and effects on autophagy, mitophagy, endocytosis, meiotic recombination, pseudohyphal growth, flocculation, and chemical resistance. Studies of related genes in other species link the family to sporulation timing, vegetative growth, apoptosis, biofilm formation, and filamentous growth.