GCN5 — Verticillium dahliae

Summary

VDAG_01089 (VdGCN5) encodes a protein with GNAT and bromodomain domains, possessing histone H3K14, H3K18, H3K9, and H3K56 acetyltransferase activities, as well as histone crotonyltransferase and H4K16ac reader activities. It acts as a transcriptional coactivator and chromatin adaptor. In Verticillium dahliae, VdGCN5 is associated with melanin anabolism, DNA repair-dependent chromatin remodeling, positive regulation of transcription elongation by RNA polymerase II, and cellular response to xenobiotic stimulus. It localizes to the nucleus, chromatin, and several complexes including the ADA, SALSA, and SAGA complexes. The gene is associated with increased sporulation rate, abnormal mitophagy, increased carbon source utilization, and abnormal chronological lifespan. Studies of related genes in other species connect the family to virulence, including reduced virulence and hypervirulence, as well as oxidative stress response.