FRDA — Verticillium dahliae

Summary

VdFRDA (VDAG_00973) on chromosome DS572696 of Verticillium dahliae encodes a flavocytochrome c with fumarate reductase (NADH) activity, cytochrome-b5 reductase activity acting on NAD(P)H, and L-lactate dehydrogenase (cytochrome) activity. The protein contains FAD-binding and cytochrome b5-like heme/steroid-binding domains and is localized to mitochondria, the ER membrane, and cytoplasm. It is associated with fumarate and lactate metabolism, electron transfer, and ergosterol anabolism. Phenotypic associations link VdFRDA to decreased necrotic cell death, increased acid pH resistance, increased hyperosmotic stress resistance, abnormal colony color, absent anaerobic growth, increased lifespan, increased mitophagy, and decreased respiratory metabolism. Studies of related genes in other species connect the family to mitochondrial genome maintenance and petite-negative growth.