PHOC — Verticillium dahliae

Summary

VDAG_00896 (VdPHOC, also known as NUC-2) encodes a multi-domain protein containing SPX, ankyrin repeat, and glycerophosphocholine phosphodiesterase domains, with annotated glycerophosphocholine phosphodiesterase, phosphoric diester hydrolase, protein-cysteine S-palmitoyltransferase, and aspartic endopeptidase activities. In Verticillium dahliae, VdPHOC is associated with Pi homeostasis, phosphoglyceride catabolism, lipid metabolism, proteolysis, and cellular response to xenobiotic stimuli. The protein localizes to the cytoplasm, early endosome membrane, and Golgi membrane. Phenotypic associations link VdPHOC to altered nutrient uptake and utilization (phosphorus, nitrogen, iron), increased stress resistance (alkaline pH, acid pH, hyperosmotic, ionic, starvation), increased autophagy and mitophagy, altered cell cycle progression (delayed G2/M transition and START), abnormal vacuolar distribution and chromosome segregation, decreased apoptosis, and increased vegetative growth rate.