FOR — Verticillium dahliae

Summary

VDAG_00824, also known as VdFOR, encodes a serine hydroxymethyltransferase (EC 2.1.2.1) with glycine hydroxymethyltransferase activity and pyridoxal phosphate binding, placing it in the Ser_HO-MeTrfase family. In Verticillium dahliae, this gene is associated with tetrahydrofolate metabolism and interconversion, programmed cell death, protein secretion, filamentous growth, and localisation to the fungal biofilm matrix, mitochondria, cytoplasm, and cytosol. The gene is linked to numerous phenotypes including abnormal cell cycle progression, altered budding patterns, decreased colony size, increased flocculation, and defects in mitochondrial genome maintenance and respiratory metabolism. Studies of related genes in other species connect the family to nutrient utilisation and turgor pressure.