SPT7 — Verticillium dahliae

Summary

VdSPT7 (VDAG_00822) in Verticillium dahliae encodes a transcriptional activator SPT7 with bromodomain and histone-fold domains. The protein possesses histone acetyltransferase activity on H3K9, H3K14, H3K18, and H4K16, is annotated as a histone reader for acetylated and crotonylated histones, and is annotated as a promoter-specific chromatin-binding transcriptional co-regulator. VdSPT7 is associated with the SAGA, ADA, and SWR-C complexes, localizes to chromatin, the nucleus, and cytoplasm, and is linked to chromatin organization, heterochromatin boundary formation, DNA repair-dependent chromatin remodeling, positive regulation of RNA polymerase II transcription, and melanin anabolism. The gene has been connected to phenotypes including decreased spore germination, absent filamentous growth, increased mutation frequency, abnormal silencing, and altered cell cycle progression. Studies of related genes in other species link the SPT7 family to virulence modulation and oxidative stress response.