FLBA — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoFLBA (FLBA, FLBB, FoSST2) on chromosome 6 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a regulator of G-protein signalling (RGS) protein with GTPase-activating protein (GAP) activity, containing DEP and RGS domains and a winged helix-like DNA-binding domain. The gene is associated with regulation of conidium formation, asexual sporulation, sterigmatocystin biosynthesis and breakdown, negative regulation of GPCR signalling, the pheromone response MAPK cascade, intracellular signal transduction, and regulation of secondary metabolite biosynthesis. It localises to the cytoplasm, cytosol, nucleus, and internal side of the plasma membrane. Phenotypic associations include altered shmoo formation, pheromone production and sensitivity, mating efficiency and response, osmotic stress resistance, endocytosis, vacuolar and nuclear transport, plasma membrane morphology, cell fusion, polyploidy, necrotic cell death, and replicative lifespan. Related genes in other species link it to developmental regulation and germination rate.