PYRG — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoPYRG (FOXG_07905) on chromosome 4 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a protein with orotidine-5'-phosphate decarboxylase and orotate phosphoribosyltransferase activities, containing OMPdecase and aldolase-type TIM barrel domains. The gene is annotated to de novo UMP biosynthesis and pyrimidine base anabolism, as well as fermentation, and the product localises to the cytosol. FoPYRG is associated with numerous phenotypes including altered adhesion, biofilm formation, filamentous and invasive growth, nutrient uptake and utilization, autophagy, stress resistance, thermotolerance, chronological lifespan, and auxotrophy. It is also linked to abnormal bud morphology, decreased anaerobic and respiratory growth, and altered RNA accumulation. Related genes in other species are linked to oxidative stress response.