URA1 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoURA1 (FOXG_08390) on chromosome 2 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a dihydroorotate dehydrogenase (quinone) (EC 1.3.5.2), a mitochondrial inner membrane enzyme that catalyzes a key step in de novo UMP and pyrimidine ribonucleotide biosynthesis. The gene is also associated with fermentation. Phenotypic associations link FoURA1 to numerous cellular processes: it is connected to abnormal colony color and morphology, increased adhesion and chitin deposition, absent or decreased sporulation, increased cell size, decreased respiratory growth and survival in stationary phase, altered RNA accumulation, decreased carbon source utilization and acquired thermotolerance, and increased prion formation. The gene is also associated with petite-negative growth and abnormal chromosome/plasmid maintenance. Studies of related genes in other species connect the family to oxidative stress response and anaerobic growth.