PRT1 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoPRT1 (FOXG_08843) on chromosome 2 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a protein belonging to the eIF3B and WD40/YVTN repeat-like domain families, with translation initiation factor binding and RNA binding activities. It is a component of the eukaryotic 43S and 48S preinitiation complexes and the eIF3 complex, and is associated with translation initiation, cytoplasmic translation initiation complex assembly, sporulation, and spore germination. The gene has been linked to numerous phenotypes including abnormal pseudohyphal and invasive growth, altered mating response, abnormal autophagy, cell cycle arrest, increased desiccation and acid pH resistance, absent anaerobic growth and adhesion, and altered protein secretion and nutrient uptake. Studies of related genes in other species connect the family to translation initiation factors eIF1A, eIF3I, eIF3G, eIF5B, and eIF3C.