ARL3 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoARL3 (FOXG_09383) on chromosome 9 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a small GTPase of the ARF family with GTP-binding and GTPase activity, and is annotated as a protein membrane adaptor. The gene is associated with diverse cellular processes including vesicle and ER-to-Golgi transport, secretion, protein transport and folding, tubulin assembly, cell growth mode switching, regulation of mitotic cytokinesis, and positive regulation of mitotic entry. It localises to the microtubule cytoskeleton, division septum, cell cortex, Golgi membrane, and COPII-coated vesicle membrane. Phenotypic associations link FoARL3 to absent sporulation and protein secretion, decreased endocytosis, meiosis, spore germination, nutrient uptake, and autophagy, as well as increased apoptosis, respiratory growth, and telomere length, and abnormal vegetative growth, budding pattern, and endomembrane system morphology. Studies of related genes in other species connect the family to reduced virulence.