PDA1 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoPDA1 (FOXG_09447) on chromosome 9 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a protein with a Pyrv_DH_E1_asu_subgrp-y, DH_E1, and THDP-binding domain, and is annotated with pyruvate dehydrogenase (lipoamide) activity and metal binding. The product localises to the mitochondrial lumen as part of the pyruvate dehydrogenase complex and is associated with the pyruvate dehydrogenase pathway, translation elongation, and mating. Associations link FoPDA1 to carbon source utilisation, cell cycle progression through G1/S and G2/M transitions, fermentative and respiratory metabolism, nuclear export, mitotic recombination, cytokinesis, vacuolar transport, autophagy, mitophagy, pexophagy, micronucleophagy, prion inheritance, silencing, X-ray resistance, and protein secretion. The gene is also connected to the TLC1, PTC5, PKP2, PKP1, PTC7, ACH1, OAF1, PTC6, TIF3, and CIT2 genes.