FLBA — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoFLBA (FLBA, FoSST2) on chromosome 11 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a regulator of G-protein signaling (RGS) protein with GTPase-activating protein (GAP) activity, containing DEP and RGS domains. The gene is associated with negative regulation of GPCR signaling, downregulation of signal transduction, and the pheromone response MAPK cascade. It is linked to regulation of conidium formation, asexual sporulation, and both positive regulation and breakdown of sterigmatocystin, as well as lipid metabolism and protein breakdown. The product localizes to the cytoplasm, nucleus, and internal side of the plasma membrane. Phenotypic associations include abnormal mating response, altered pheromone sensitivity and shmoo formation, increased chemical compound excretion, and altered endocytosis, vacuolar transport, and osmotic stress resistance. Studies of related genes in other species link the family to germination rate and oxidative stress response.