THI2 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoTHI2 (FOXG_10428) on chromosome 7 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a member of the Thi4 family with FAD/NAD-binding superfamily domains and suicide thiamine thiazole synthase activity, also binding ferrous iron. The gene is associated with thiazole and thiamin biosynthesis, RNA splicing, and localisation to both the cytosol and nucleus. It has been linked to oxidative stress response and a wide range of phenotypes including abnormal actin cytoskeleton, spindle pole body, and nuclear morphology; increased apoptosis, telomere length, and heat sensitivity; arrested G2/M cell cycle progression; decreased competitive fitness and toxin resistance; and inviability. Studies of related genes in other species connect the family to increased biofilm formation, altered fermentative metabolism, and increased mitochondrial rho- mutation frequency.