RHO1 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FOXG_11053 (symbol RHO1) on chromosome 1 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a small GTPase of the Rho family, possessing GTPase activity, GTP binding, and protein ser/thr kinase activator activity. This gene is associated with Rho protein signal transduction, small GTPase-mediated signal transduction, and positive regulation of the cell integrity MAPK cascade. It is linked to the regulation of fungal-type cell wall biogenesis, including 1,3-beta-glucan anabolism and 1,3-alpha-glucan anabolism, as well as the regulation of endocytosis, vacuole fusion, and protein localization. RHO1 is also associated with cellular processes such as budding cell bud growth, septin ring organization, and mitotic actomyosin contractile ring assembly. The encoded protein localizes to the hyphal tip, new and old growing cell tips, cellular bud tip and neck, the 1,3-beta-glucan synthase complex, and extracellular vesicles. Studies of related genes in other species link the family to loss of pathogenicity.