CHS1 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoCHS1 (CHS1) on chromosome 13 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a chitin synthase, an enzyme with chitin synthase activity that belongs to the chitin synthase family. The gene is associated with cell wall biogenesis, chitin anabolism, cell wall organization, hyphal growth, and conidia formation. It is linked to the plasma membrane, hyphal tip, porous cell septum, and cross wall. FoCHS1 is associated with numerous phenotypes including abnormal septum formation, absent budding, decreased flocculation, abnormal chitin deposition, decreased cell fusion, increased pheromone sensitivity, abnormal spore wall formation, and altered cell cycle progression, including G2 phase duration and late anaphase arrest. Studies of related genes in other species link the family to reduced virulence and lethal phenotypes.