APR1 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoAPR1 (FOXG_12714) on chromosome 9 of Fusarium oxysporum f. sp. lycopersici encodes an aspartic peptidase A1 family protein with aspartic endopeptidase activity, oligosaccharide binding, and disordered domain specific binding. The gene is associated with proteolysis, pexophagy and microautophagy, cytoplasm-to-vacuole targeting, mating, and translation elongation. It localises to the vacuolar lumen, fungal-type vacuole, extracellular region, and macromolecular complexes. Phenotypic associations link FoAPR1 to abnormal sporulation, cell cycle arrest, defective nuclear fusion during mating, delayed autophagy and pexophagy, aberrant vesicle distribution, endocytosis, vacuolar transport, plasma membrane morphology, and chemical compound accumulation, small molecule transport, respiratory and fermentative metabolism, mitochondrial genome maintenance, and mutation frequency. Studies of related genes in other species connect the family to reduced virulence and altered cell death responses.