ARF3 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoARF3 (FOXG_13731) on chromosome 10 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a small GTPase of the ARF/SAR family, with GTP-binding and GTPase activity, and is annotated as a protein membrane adaptor. The gene is associated with multiple cellular processes including ER-to-Golgi transport, vesicle transport, protein transport, tubulin assembly, regulation of mitotic cytokinesis, and cell growth mode switching from monopolar to bipolar. It localises to the microtubule cytoskeleton, division septum, cell cortex, Golgi complex, and plasma membrane. Phenotypically, FoARF3 is linked to abnormal spore germination, filamentous growth, and absent bipolar budding pattern, as well as altered cell cycle progression, decreased cytokinesis rate, increased anaerobic growth, and absent desiccation resistance. The gene also shows associations with delayed protein secretion and decreased redox state.