brlA — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FOXG_14132 (symbol brlA) on chromosome 6 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a C2H2-type zinc-finger protein that is a sequence-specific DNA-binding transcription factor, with activity linked to RNA polymerase II cis-regulatory regions and zinc binding. The gene is associated with conidia formation, sporulation, and sporocarp development involved in sexual reproduction, as well as regulation of secondary metabolite biosynthesis and negative regulation of transcription by RNA polymerase II. Its product localizes to the nucleus, membrane, and Ste12p-Dig1p-Dig2p and Tec1p-Ste12p-Dig1p complexes. Studies of related genes in other species link the family to loss of pathogenicity and reduced virulence, and to associations with hosts such as rice and Galleria mellonella.