MUC1 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoMUC1 (FOXG_12728) on chromosome 9 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a Gti1/Pac2 family protein with sequence-specific DNA binding and transcription factor activity. The gene is associated with the regulation of phenotypic switching, conidia and spore formation, filamentous growth, mating, meiotic cell cycle, and biofilm formation on inanimate substrates. It is linked to symbiotic interaction processes including adhesion of symbiont to host, parasexual conjugation with cellular fusion, and upregulation of gluconate transport. The product localises to the nucleus, chromatin, cytosol, and mitotic spindle pole body. Studies of related genes in other species connect the family to reduced virulence, decreased vegetative growth, and changes in stress resistance, as well as associations with fusarium wilt and head blight diseases.