PGK — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoPGK (FOXG_11669) on chromosome 10 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a phosphoglycerate kinase, an enzyme with phosphoglycerate kinase activity that binds ADP and ATP. It is associated with canonical glycolysis, gluconeogenesis, and fermentation, and has been linked to negative regulation of pyruvate decarboxylation to acetyl-CoA. The protein localises to the cytosol, mitochondria, and nucleus. Associations with respiration rate and numerous phenotypes—including increased cell cycle progression through S phase and G1/S transition, decreased cell death, increased adhesion and mating efficiency, abnormal prion inheritance and formation, delayed autophagy, and altered colony morphology—have been recorded. The gene is also connected to the Fol:4DPI, Fol:6DPI, and Fol:2DPI infection time points.