CHS1 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoCHS1 (FOXG_10443) on chromosome 7 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a chitin synthase with chitin synthase activity, belonging to the chitin synthase family. The gene is associated with cell wall biogenesis and organization, chitin anabolism, septum positioning, mitotic actomyosin contractile ring contraction, conidia formation, and homologous recombination. Its product localizes to the plasma membrane, cross wall, cell periphery, and cellular bud neck. FoCHS1 is linked to numerous phenotypes including abnormal septum formation, absent cell fusion, decreased flocculation and adhesion, abnormal bipolar budding and bud neck morphology, altered chitin deposition, decreased chromosome segregation, increased pheromone sensitivity, abnormal spore wall formation, and altered cell cycle progression including G2 phase duration and late anaphase arrest. Studies of related genes in other species link the family to reduced virulence and vegetative growth.