LAC1 — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoLAC1 (FOXG_09367) on chromosome 9 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a protein with a Lag1/Lac1-like domain, a TRAM1 domain, and a TLC domain, and is annotated to ceramide synthase activity. It is localised to the endoplasmic reticulum membrane. The gene is associated with ceramide anabolism, sphingolipid anabolism, detoxification, the meiotic cell cycle, and endocytosis. Numerous phenotypes are associated with this gene, including increased resistance to alkaline and acid pH, hyperosmotic and osmotic stress, altered endocytosis, decreased apoptosis, delayed cell cycle progression in G1 phase, abnormal budding, decreased chitin deposition, altered mating response, and changes in stationary-phase survival and starvation resistance. The gene is also linked to the proteins DGT1, FUM17, FUM18, and ALT7, and to related genes including YDC1, YPC1, LIP1, and ORM1/ORM2.