FLBA — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoFLBA (FOXG_08482) on chromosome 2 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a regulator of G-protein signaling (RGS) protein containing DEP and RGS domains, with GTPase-activating protein (GAP) activity. The gene is associated with negative regulation of GPCR signaling, downregulation of signal transduction, and the pheromone response MAPK cascade. It has been linked to regulation of conidium formation, asexual sporulation, and both sterigmatocystin breakdown and biosynthesis. Localization evidence links the product to the cytoplasm, nucleus, and internal side of the plasma membrane. Phenotypic associations include altered shmoo formation, pheromone sensitivity and production, mating response, endocytosis, vesicle distribution, osmotic stress resistance, and vegetative growth. Related genes in other species link the family to virulence, pathogenicity, and stress responses, including associations with fusarium wilt and head blight.