CALA — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoCALA (FOXG_07814) on chromosome 4 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a calcineurin-like serine/threonine protein phosphatase with calmodulin-dependent protein phosphatase activity, ferric iron binding, and RNA polymerase II C-terminal domain phosphatase activity. The gene is associated with calcineurin-mediated signaling, regulation of cell budding and morphogenesis, cell polarization, septation, cytokinesis, glycogen anabolism, clathrin-mediated endocytosis, centromere clustering, and cellular ion homeostasis. It is linked to the calcineurin complex, DPS complex, bud neck septin collar, and PTW/PP1 phosphatase complex. Phenotype associations include abnormal spore germination, altered budding rate, increased endocytosis, absent meiosis, increased freeze-thaw resistance, and decreased nitrogen source utilization. Studies of related genes in other species link the family to loss of pathogenicity and reduced virulence.