FLBA — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoFLBA (FLBA, FOXG_06767) on chromosome 3 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a regulator of G-protein signaling (RGS) protein with GTPase-activating protein (GAP) activity, containing DEP and RGS domains. It is associated with sterigmatocystin breakdown and positive regulation of sterigmatocystin biosynthesis, as well as regulation of conidium formation, asexual sporulation, and the pheromone response MAPK cascade. The gene is linked to negative regulation of GPCR signaling, intracellular signal transduction, and regulation of secondary metabolite biosynthesis. Phenotypic associations include abnormal mating response, altered pheromone sensitivity and production, increased chemical compound excretion, and abnormal shmoo formation, endocytosis, and vacuolar transport. The protein localizes to the cytoplasm, nucleus, and internal side of the plasma membrane. Related genes in other species link it to developmental regulation and germination rate.