FLBA — Fusarium oxysporum f. sp. lycopersici 4287

Summary

FoFLBA (FLBA) on chromosome 6 of Fusarium oxysporum f. sp. lycopersici 4287 encodes a regulator of G-protein signaling (RGS) protein with GTPase-activating protein (GAP) activity, containing DEP and RGS domains. The gene is associated with negative regulation of GPCR signaling, the pheromone response MAPK cascade, and regulation of conidium formation and asexual sporulation. It is linked to sterigmatocystin breakdown and positive regulation of sterigmatocystin biosynthesis, as well as regulation of secondary metabolite biosynthesis and transcription by RNA polymerase II. The product localizes to the cytoplasm, nucleus, and internal side of the plasma membrane. Phenotypic associations include abnormal mating response and pheromone sensitivity, increased chemical compound excretion, and absent osmotic stress resistance. Related genes in other species link the family to developmental regulation and germination rate.